报告题目:Evolution of Metabolism in Model Organism and Human
报 告 人:顾正龙 教授(美国康奈尔大学)
报告时间:4月17日(星期四)9:30 –10:30
报告地点:海洋之神8590vip天津工业生物技术研究所 C408报告厅
附:报告人简历
Zhenglong Gu(顾正龙)
Education(教育背景):
· PhD in Ecology and Evolution, University of Chicago, 2003
· 生态学与进化专业博士学位,美国芝加哥大学,2003年
· BS in Biochemistry and Molecular Biology, Peking University, 1998
· 生物化学与分子生物学学士学位,北京大学,1998年
Biographical Statement(工作经历及研究方向):
· Dr. Zhenglong Gu conducted his postdoctoral research at Stanford Genome and Technology Center from 2004 to 2006. He became an Assistant Professor in the Division of Nutritional Sciences at Cornell University in 2006.
· 2004-2006年,于美国斯坦福大学基因组技术中心从事博后研究工作;
· 2006年于美国康奈尔大学营养科学系被评为副教授;
· Dr. Gu's laboratory uses a combination of computational and experimental approaches to understand the structure of metabolic networks and how these have been shaped over evolutionary time by selective pressures, such as those imposed by nutrient constraints. Much of the effort is devoted to understanding these issues in Saccharomyces cerevisiae, because of its simplicity, rapid growth and the availability of robust experimental and computational tools. Specific interests include evolution of aerobic fermentation in yeast and its implication in ethanol production and cancer physiology, duplicate gene regulation and evolution of antagonistic pleiotropy, genetic and evolution of complex life traits in pathogenic fungi. His laboratory also has interests in using computational and experimental approach to investigate function, evolution and diseases relevance for mitochondria.
· 课题组利用计算和实验相结合的方法来探究代谢网络的结构,以及在选择性压力条件下(如营养限制)这些代谢网络结构的形成机理。酿酒酵母以其易操作、生长较快和在实验和计算两方面都具有很强的利用性的特点,成为本课题组的主要研究对象。具体的研究方向包括:酵母的有氧发酵进化研究,及该过程对乙醇产生、癌症生理学和多基因调控的影响;病原菌的多效性进化研究、复杂的生命特征的遗传和进化研究。除此之外,课题组还对线粒体的功能、进化及其疾病相关性研究感兴趣。